Serum Visfatin As a Novel Marker of Endothelial Dysfunction in Patients with Type 2 Diabetes

Introduction: Atherosclerotic vascular complications are the main cause of premature morbidity and mortality of patients with CKD.Endothelial dysfunction is an early predictor of atherosclerosis.Visfatin levels negatively correlated with glomerular filtration rate (GFR) and endothelial function.Aim: The aim of this study is to evaluate serum visfatin level in patients with type 2 diabetic nephropathy patients and to find its association with microalbuminuria.Material and methods: Sixty type 2 diabetic subjects (T2DM) with more than 5 year diabetic duration in the age group of 35 to 60 years and thirty age and sex matched healthy controls were selected for the study.Serum visfatin, insulin levels and urine microalbumin were assessed.Results: There was significant increase in the level of plasma visfatin, urinary visfatin in microalbuminuric diabetic patients compared to normoalbuminuric diabetic patients. Conclusion:it is presumed that Plasma visfatin can be a novel surrogate marker for the clinical assessment of endothelial dysfunction and CVD risk in type 2 diabetes.