In-vivo imaging of neurological signatures using coherent optical techniques (Conference Presentation)

Optical neuroimaging technologies aim to observe neural tissue structure and function by detecting changes in optical signals (scatter, absorption, etc…) that accompany a range of anatomical and functional properties of brain tissue. At present, there is a tradeoff between spatial and temporal resolution that is not currently optimized in a single imaging modality. We have developed a coherent optical imaging approach that begins to remove this trade-off and have demonstrated high spatiotemporal (<100µm and >100Hz) in-vivo recordings of neural activity over large 20mm2 areas.