MuRF1 and MuRF2 Are Key Players in Skeletal Muscle Regeneration Involving Myogenic Deficit and Deregulation of the Chromatin‐remodeling Complex

Skeletal muscle regeneration is a powerful and highly synchronized process and it is well described that intracellular pathways related to anabolic responses are readily activated. On the other hand, the role of catabolic pathways in the skeletal muscle regenerative response is much less understood. In the present study, we hypothesized that MuRF1, a key gene involved in skeletal muscle mass loss, and its close counterpart MuRF2 play a role in skeletal muscle regeneration.