Altered Fgf21 Response in Alcohol Induced “Acute-on-chronic Liver Injury” (ACLI) Model

E Karatayli,G Christidis,RA Hall,SN Weber,S Dooley,F Lammert,SC Karatayli

Zeitschrift für Gastroenterologie（2019）

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摘要

The fibroblast growth factor (FGF) 21 acts as the main regulator of glucose and lipid homeostasis, and has recently been shown to have a potential role in bile acid metabolism. In this study, we aim to investigate FGF21 response in an ethanol induced acute on chronic liver injury (ACLI) model in Abcb4-/- mice, which is a reproducible model for chronic biliary liver disease.

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