CVB5 Proteases 2A Targets Insulin Granule Biogenesis in MIN6 Cells

Coxsackieviruses B (CVBs) are among the candidate environmental factors implicated in the pathogenesis of type 1 diabetes. Their cap-independent translation in β-cells relies on factors that are also implicated in the translation of insulin granule components (Knoch et al, 2014). Notably, CVB Infection of β-cells strongly reduces their insulin granule stores and release. Therefore, we are interested in elucidating how CVB proteases affect the traffic and stability of insulin granule cargoes.