Endocrine Dysfunctions in Adults Post Hematopoietic Stem Cell Transplantation

Introduction: Hematopoietic stem cell transplantation (HSCT) is the standard treatment for some malignancies and hematological diseases.Many patients/year undergoes this procedure and were at high risk of development long-term complications, including endocrine dysfunctions.The aim of this study is to evaluate the frequency and nature of endocrine disorders in adult patients undergoing HSCT in Brazil. Materials and methods:Retrospective study from medical records of 494 post-HSCT patients, referred for follow-up in the Endocrinology Clinic of the National Cancer Institute (INCA).Results and discussion: Three hundred forty-two patients met criteria for inclusion, of these 52.3% had endocrine complications post-HSCT.The main endocrine dysfunction was hypogonadism, followed by hypothyroidism, hypocortisolism and hypopituitarism.Graft-versus-host disease was diagnosed in 42.4% of total population.Seventy-three (21.3%) patients of the cohort died during follow-up.Endocrine dysfunctions are common complications of HSCT.Early diagnosis and treatment can improve the quality of life and morbidity.