A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables “Last-Step”18F Fluorination of a RGD Peptide under Ambient Aqueous Conditions

Stephen Thompson,Qingzhi Zhang,Mayca Onega,Stephen McMahon,Ian Fleming,Sharon Ashworth,James H. Naismith,Jan Passchier,David O'Hagan

Angewandte Chemie International Edition（2014）

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The authors thank the ERC, EPSRC and the Scottish Imaging Network (SINAPSE) for grants, and the John and Kathleen Watson Scholarship (S.T.) for financial support.

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关键词

fluorinase enzyme,rgd peptide,substrate specificity,last-step

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