Current Status of Precision Medicine in Pediatric Oncology in Spain: a Consensus Report by the Spanish Society of Paediatric Haematology and Oncology (SEHOP)
Clinical and Translational Oncology（2022）
Research Institute Hospital La Fe | Hospital Universitario Niño Jesús | La Fe University Hospital | Children’s University Hospital Niño Jesús | Vall d’Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB) | INGEMM-IdiPAZ | Hospital Sant Joan de Déu | Hospital Infantil Virgen del Rocio | Madrid Montepríncipe Hospital | Health in Code Group | Virgen del Rocío University HospitalCSICUniversity of SevillaCIBERONC | Hospital Universitario La Paz | Bio Cruces Health Research Institute | University Clinic of Navarra and Solid Tumor Area | Unidad de Tumores Sólidos Infantiles | Hospital Universitario Virgen Macarena
Abstract
The study analyzes the current status of personalized medicine in pediatric oncology in Spain. It gathers national data on the tumor molecular studies and genomic sequencing carried out at diagnosis and at relapse, the centers that perform these studies, the technology used and the interpretation and clinical applicability of the results. Current challenges and future directions to achieve a coordinated national personalized medicine strategy in pediatric oncology are also discussed. Next generation sequencing-based (NGS) gene panels are the technology used in the majority of centers and financial limitations are the main reason for not incorporating these studies into routine care. Nowadays, the application of precision medicine in pediatric oncology is a reality in a great number of Spanish centers. However, its implementation is uneven and lacks standardization of protocols; therefore, national coordination to overcome the inequalities is required. Collaborative work within the Personalized Medicine Group of SEHOP is an adequate framework for encouraging a step forward in the effort to move precision medicine into the national healthcare system.
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Key words
Personalized medicine,Pediatric oncology,Next generation sequencing,Onco-genomics,Molecular biomarkers,Targeted therapies
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