Construction of Genetic Classification Model for Coronary Atherosclerosis Heart Disease Using Three Machine Learning Methods.

Cited 5|Views2

Abstract

Background Although the diagnostic method for coronary atherosclerosis heart disease (CAD) is constantly innovated, CAD in the early stage is still missed diagnosis for the absence of any symptoms. The gene expression levels varied during disease development; therefore, a classifier based on gene expression might contribute to CAD diagnosis. This study aimed to construct genetic classification models for CAD using gene expression data, which may provide new insight into the understanding of its pathogenesis. Methods All statistical analysis was completed by R 3.4.4 software. Three raw gene expression datasets (GSE12288, GSE7638 and GSE66360) related to CAD were downloaded from the Gene Expression Omnibus database and included for analysis. Limma package was performed to identify differentially expressed genes (DEGs) between CAD samples and healthy controls. The WGCNA package was conducted to recognize CAD-related gene modules and hub genes, followed by recursive feature elimination analysis to select the optimal features genes (OFGs). The genetic classification models were established using support vector machine (SVM), random forest (RF) and logistic regression (LR), respectively. Further validation and receiver operating characteristic (ROC) curve analysis were conducted to evaluate the classification performance. Results In total, 374 DEGs, eight gene modules, 33 hub genes and 12 OFGs ( HTR4 , KISS1 , CA12 , CAMK2B , KLK2 , DDC , CNGB1 , DERL1 , BCL6 , LILRA2 , HCK , MTF2 ) were identified. ROC curve analysis showed that the accuracy of SVM, RF and LR were 75.58%, 63.57% and 63.95% in validation; with area under the curve of 0.813 (95% confidence interval, 95% CI 0.761–0.866, P < 0.0001), 0.727 (95% CI 0.665–0.788, P < 0.0001) and 0.783 (95% CI 0.725–0.841, P < 0.0001), respectively. Conclusions In conclusion, this study found 12 gene signatures involved in the pathogenic mechanism of CAD. Among the CAD classifiers constructed by three machine learning methods, the SVM model has the best performance.

Translated text

Key words

Coronary atherosclerosis heart disease,Classification model,Machine learning,Support vector machine,Random forest,Logistic regression

求助PDF

上传PDF

Bibtex

AI Read Science

AI Summary

AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.

Example

Background

Key content

Introduction

Methods

Results

Related work

Fund

Key content

Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

Upload PDF to Generate Summary

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper