A simple synthetic entryway into new families of NHC-gold-amido complexes and their in vitro antitumor activity
Dalton transactions (Cambridge, England : 2003)(2022)
摘要
A simple synthetic pathway to Au-NHC amido complexes is described. Syntheses and isolation of [Au(NHC)((NRR2)-R-1)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells.
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