Clinical Evaluation of Switching from Immediate‐release to Prolonged‐release Lithium in Bipolar Patients, Poorly Tolerant to Lithium Immediate‐release Treatment: A Randomized Clinical Trial

Federica Pelacchi,Liliana Dell'Osso,Emi Bondi,Mario Amore,Andrea Fagiolini, Paolo Iazzetta, Daniela Pierucci, Manuela Gorini, Elisa Quarchioni,Alessandro Comandini,Enrica Salvatori,Agnese Cattaneo,Maurizio Pompili

Brain and behavior（2022）

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摘要

The effect of switching from lithium immediate release (Li‐IR) to lithium prolonged release (Li‐PR) on lithium‐induced tremor after 1 and 12 weeks of treatment was evaluated in a randomized, multicenter, open trial, in bipolar patients from the participating sites with a tremor severity ≥2 (Udvalg for Kliniske Undersøgelser [UKU] rating scale) despite optimal lithium titration.

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关键词

bipolar disorder,lithium compounds,tremor

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