Neuroinflammation in COVID-19 and ADRD: Similarities, differences, and interactions.

Given the crucial role of inflammation and immune system functioning in both these conditions, implementing preventative measures to strengthen the immune system and decrease comorbid conditions and lifestyle risk factors is imperative, especially for vulnerable populations. Mapping approaches such as AOPs can be particularly helpful in evaluating the weight of current evidence and knowledge gaps in a rapidly evolving scientific data landscape, such as the COVID-19 pandemic. These approaches can also serve as a foundation to further probe the complexities of multiscale interactions in diseases that may otherwise initially appear unrelated.