Expression Quantitative Trait Loci (eqtl) Analysis in a Diverse Alzheimer Disease Cohort Reveals Ancestry-Specific Regulatory Architectures.

Anthony J Griswold,Olivia K Gardner,Briseida E Feliciano-Astacio,Derek Van Booven,Kara L Hamilton-Nelson,Patrice L Whitehead,Larry D Adams,Takiyah D Starks,Heriberto Acosta, Michael L Cuccaro,Jeffery M Vance,Goldie S Byrd,Jonathan L Haines,William S Bush,Gary W Beecham,Margaret A Pericak-Vance

PubMed（2021）

Cited 1|Views11

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Abstract

AA, NHW, and PR individuals have overlapping regulatory architecture that likely reflects the admixture in AA (20% European, 80% African) and PR (∼60% European, 20% African, and 20% Amerindian). These results underscore the importance of continuing to include diverse populations in AD genomics and functional studies to identify unique and shared architecture of AD.

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