Metabolome alterations in Clonorchis sinensis after treatment with tribendimidine and praziquante in vivo

Wei Yufen,Liu Xinru,Xue Jian, Huolele,Jiang Zhihua,Chen Yu, Liang Mingyong,Zhang Haobing

Acta Tropica（2022）

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摘要

•The metabolomes of C. sinensis in rats after TBD/PZQ administration were measured.•TBD administration caused an alteration in amino acids and lysophospholipids.•The membrane may destroyed by lysophospholipids, which lead to C. sinensis death.

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关键词

Metabolome alterations,Tribendimidine,Praziquante,Clonorchis sinensis,Amino acids,Phospholipids,Fatty acids

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