Four AAs Increase DMT1 Abundance in Duodenal Brush-Border Membrane Vesicles and Enhance Iron Absorption in Iron-Deprived Mice.

Regina R. Woloshun,Yang Yu,Xiaodong Xu,Jennifer K. Lee,Sean Zhu,Jacob S. Shine,Pearl Ebea,Bruce R. Stevens,Sadasivan Vidyasagar,James F. Collins

Blood advances（2022）

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摘要

Key Points Oral iron supplementation is usually recommended to treat iron-deficiency anemia; however, excess enteral iron has negative side effects. We identified 4 AAs that stimulate intestinal iron absorption and may potentiate iron repletion at lower effective supplemental doses.

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