Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies db2.tmp srctitleChangeRecord1-20220420.115456.log srctitleChangeRecord2-20220420.120439.log srctitle_new2.ksh srctitle_new3.ksh WOSType1.TXT WOSType2.TXT

Melanoma is an aggressive form of skin cancer that, when localized, is highly curable with a simple surgical excision. However, as it grows in the span of just a few millimeters, its lethality increases markedly. More so than many other cancers, the management of melanoma is governed by phase III randomized trials in almost every aspect of treatment. Over the last 10 years, not only have there been several landmark surgical trials but also major advances in systemic treatments using targeted and immunologic approaches to metastatic disease. The availability of effective systemic therapies has led to rapid improvements in survival as well as significant alterations in the traditional approaches to managing this disease. This monograph is organized into 6 sections that provide focused updates on the advances in various aspects of melanoma care. These sections incorporate the latest findings and will help with the management of individual