Sensitivity Analysis of a Nuclear Electroporation Model—A Theoretical Study

In this paper, a theoretical study on the sensitivity of the nuclear electroporation model to real values is developed. This work has two main objectives. The first one is to study the sensitivity of a nuclear electroporation model to pulses of the order of ns. The second objective is to provide a guide for cell membrane and nuclear envelope electroporation for nanosecond pulses applications. A bibliographic review is performed to gather data used in experiments and other theoretical studies, and this data is used within an optimization routine to find the electroporation threshold as a function of stimulation pulse parameters. The nuclear electroporation threshold is plotted, and the model sensitivity is calculated and compared. The model is more sensitive to nuclear electrical properties, although some cellular parameters show a slight, but not negligible, influence. These results are summarized in two graphs that serve as an electroporation guide for ns pulses.