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Cognitive Decline and Risk of Dementia in Individuals with Heart Failure: A Systematic Review and Meta-analysis

Journal of Cardiac Failure(2022)

Monash Univ | Kings Coll London | School of Public Health and Preventive Medicine

Cited 13|Views8
Abstract
Background: We sought to determine the association between heart failure (HF) and cognitive change and dementia. Methods and Results: Systematic search of three electronic databases was performed and 29 eligible studies involving approximately 3 million participants were identified. Twelve studies examined dementia and 20 cognitive change, but only a subset of studies could be included in the meta-analysis. These findings indicated that HF was not significantly associated with dementia (n = 8, hazard ratio 1.18, 95% confidence interval 0.93-1.50), but increased the risk of cognitive impairment (n = 3, hazard ratio 1.80, 95% confidence interval 1.14-2.86). Additionally, HF was associated with poorer mean cognitive performance in global cognition (Hedges' g -0.73, 95% confidence interval -1.12 to -0.35), memory (Hedges' g -0.57, 95% confidence interval -0.72 to -0.42), executive function (Hedges' g -0.58, 95% confidence interval -0.72 to -0.43), attention/speed (Hedges' g -0.50, 95% confidence interval -0.63 to -0.37) and language (Hedges' g -0.61, 95% confidence interval -1.05 to -0.17). Conclusions: Patients with HF perform worse on all cognitive tests and have an increased risk of cognitive impairment. These findings highlight the need for clinicians to consider cognition as part of routine care for patients with HF.
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Key words
Heart failure,cognition,cognitive decline,cognitive impairment,dementia,Alzheimer's disease
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要点】:本文通过系统回顾和荟萃分析发现,心衰患者认知功能下降和痴呆风险增加,尤其是认知障碍风险显著提高。

方法】:作者对三个电子数据库进行了系统检索,共识别出29项符合条件的研究,涉及约300万参与者。

实验】:部分研究被纳入荟萃分析,结果显示心衰与痴呆症之间没有显著相关性,但增加了认知障碍的风险,并在全球认知、记忆、执行功能、注意/速度和语言方面的平均认知表现较差,使用的数据集和研究结果未在摘要中明确提及。