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    • 度中心性的静息态功能磁共振成像探讨原发性痛经患者月经期痛经的中枢机制

    霍健伟,郝瑛,刘妮,黄怡然,李文迅,刘志丹,吴俊辰,夏晶,张亚男,李莹秋

    Chinese Journal of Magnetic Resonance Imaging（2021）

    Cited 4|Views11
    Abstract
    目的应用静息态功能磁共振度中心性(degree centrality,DC)的分析方法探讨原发性痛经(primary dysmenorrhea,PDM)患者月经期痛经的中枢机制.材料与方法招募35例患者(PDM组)及41例健康女性(healthy controls,HC组)为研究对象,进行疼痛及焦虑视觉模拟评分、痛经的伴随症状评分,同时采集静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)数据,使用DPABI软件对数据进行预处理,分析两组间DC值的差异及差异脑区的DC值与临床资料的相关性.结果双侧额中回、左侧眶部额上回及楔前叶DC值PDM组明显高于HC组;而在左侧脑干、颞上回及颞中回PDM组DC值显著低于HC组(GRF校正,体素水平P<0.001,团块水平P<0.05,双侧);其中PDM组右侧额中回DC值与病程负相关(r=0.383,P=0.023).结论PDM患者月经期痛经的中枢机制中,前额叶区域可能参与了月经期大脑对疼痛认知调节的代偿性活动,而楔前叶则可能参与了中枢痛觉敏化的机制;小脑与脑干可能也参与了疼痛相关处理过程.
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    【要点】：该研究采用静息态功能磁共振成像及度中心性分析方法，探讨了原发性痛经患者月经期痛经的中枢机制，发现前额叶和楔前叶等脑区在痛经过程中可能具有不同的功能作用。
    

    【方法】：研究通过招募35例原发性痛经患者和41例健康女性作为研究对象，进行疼痛及焦虑评分和痛经伴随症状评分，并采集静息态功能磁共振成像数据，使用DPABI软件对数据预处理后，分析两组间度中心性值的差异及差异脑区与临床资料的相关性。
    

    【实验】：实验数据采集后，使用DPABI软件对rs-fMRI数据进行预处理，并进行了度中心性分析，发现PDM组在双侧额中回、左侧眶部额上回及楔前叶的度中心性值明显高于HC组，而在左侧脑干、颞上回及颞中回的度中心性值显著低于HC组，且PDM组右侧额中回的度中心性与病程负相关。