Migraine, Osmophobia and Central Sensitizations: Observational Retrospective Multifactorial Study in a Terziary Headache Center

Osmophobia, defined in medical dictionaries as a morbid fear of smells. Incidence based on the different diagnosis of headaches. Olfactory hypersensitivity, anxiety and pain share common neural pathways and area activation, a possible functional association and an interaction of one with the other might be argued, basing both on imaging data and on the clinical experience. The aim of this study was to investigate the relationship between osmophobia and clinical features in headache patients. It has been supposed that osmophobia play a role in the process of a central sensitization.