Basic Research in Sexology

S, Klinička psihologija 9 (2016), 1, 5-190 126 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0008 KH-204 PROTECTS OXDIDATIVE STRESS-INDUCED TESTICULAR APOPTOSIS BY ERK AND AKT PATHWAYS W. Bae, J.B. Choi, K.S. Kim, S.J. Kim, H.J. Cho, U.S. Ha, S.H. Hong, J.Y. Lee, S.W. Kim Department of Urology, Seoul St. Mary’s Hospital, Seoul, SOUTH KOREA bwoong@catholic.ac.kr Objective: Korean herbal formulation, Ojayeonjonghwan is used to treat lateonset hypogonadism (LOH) symptoms including erectile dysfunction (ED). Previous study demonstrated that the modified Ojayeonjonghwan (KH-204) can be developed as a therapeutic alternative medicine to improve ED. We examined the pharmacological effects of KH-204 in vitro and in a LHRH agonist-induced LOH rat model. Design and Method: TM3 Leydig cell viability was measured based on oxidative stress according to the treatment. We investigated either distilled water (shamoperated) or leuprorelin 0.5mg/kg, which was subcutaneously administered once to the back of rats. Male rats were divided into four groups (n = 8 in each): a normal control group, an androgen-deprived control group and two androgen-deprived groups treated p.o. with either 200 or 400 mg/kg, KH-204 for 4 weeks. The testes and epididymides from rats in all groups were removed, weighed and subjected to histological examination after treatment. Results: KH-204 protected TM3 cells from oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in androgen-deprived or aging male rats were significantly enhanced, and germ cell apoptosis was reduced after treatment. Conclusions: These results suggested that KH-204 may alleviate the oxidative stress via ERK and Akt pathways, and it may contribute to the improvement of serum testosterone levels. ABSTRACTS, Klinička psihologija 9 (2016), 1, 5-190S, Klinička psihologija 9 (2016), 1, 5-190 127 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0001 THE EFFECT OF SEXUAL AROUSAL ON WOMEN ́S DISGUST REACTIONS: FACIAL ATTRACTIVENESS AND DISEASE CUES F. Zsok, D.S. Fleischman University of Portsmouth, Portsmouth, UNITED KINGDOM zsok@outlook.de Objective: Disgust and sexual arousal are two opposing states. One motivates avoidance, while the other elicits approaching behaviour. Former research has found that a person is harder to sexually arouse if disgusted. In turn, the effects of sexual arousal on disgust are more differentiated. A general trend shows that people are less disgust sensitive when they are sexually aroused, but this appears to depend on what elicits the disgust. This study is supposed to explore what exactly becomes less disgusting when women are sexually aroused. Design and Method: Female undergraduates are going to participate in an experiment from their personal computer at home. They are going to be shown a video, either a sexually arousing one or a neutral one. Then, they will be asked to rate their disgust towards increasingly sexual behaviours with six men on pictures. The pictures will consist of attractive, unattractive, and blemished and unblemished faces. That way the effects and interactions of sexual arousal, attractiveness, and disease cues (blemishes) can be explored. Results: The study is currently running and should be completed at the end of February. We expect results to show that sexually aroused women feel less disgusted towards activities with attractive males. Disease cues should dampen the effect of sexual arousal on disgust. Conclusions: Expected results would support the evolutionary view that disgust is only reduced by sexual arousal if the mating encounter seems beneficial for the female. ABSTRACTS, Klinička psihologija 9 (2016), 1, 5-190S, Klinička psihologija 9 (2016), 1, 5-190 128 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0002 WHITE MATTER DYSCONNECTIVITY IN PANIC DISORDER WITH EARLY SEXUAL ABUSE HISTORY: A PRELIMINARY STUDY S. Yu, S. Lee Bundang Cha Hospital, Seongnam, SOUTH KOREA styu95@gmail.com Objective: People who have experienced childhood abuse are more likely to experience frequent or generalized anxiety or panic disorder (PD). Although previous studies have used magnetic resonance imaging (MRI) to demonstrate structural abnormalities of brain in subjects with PD, there are no study about the brain white matter (WM) connectivity differences between PD with and without early sexual abuse. The objective of this study is to compare the brain WM connectivity between PD with and without early sexual abuse history. Design and Method: Twelve right-handed patients with PD [12 women; 35.91±10.29 (mean±SD) age] who met the diagnostic criteria in Structured Clinical Interview for DSM-IV were examined by means of MRI at 3 Tesla. We divided the patients with PD into two groups with and without early sexual abuse to compare the WM connectivity. Panic Disorder Severity Scale (PDSS), Beck Depression Inventory (BDI) and Anxiety Sensitivity Index-Revised (ASI-R) were administered in PD patients. Results: Tract-based spatial statistics showed that fractional anisotropy (FA) values in PD with sexual abuse history were significantly higher than PD without abuse in the right internal capsule, superior corona radiata, sagittal stratum, fornix. The scores of PDSS, BDI, ASI-R were significantly correlated in the above-mentioned WM regions. Conclusions: This preliminary study suggests that early sexual abuse could influence the connectivity among emotion related limbic structures in PD. ABSTRACTS, Klinička psihologija 9 (2016), 1, 5-190S, Klinička psihologija 9 (2016), 1, 5-190 129 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0003 EFFECT OF OXYTOCIN ON THE CONTRACTILE RESPONSE IN RAT VAGINA K. Park1, S. Kim1, Z. Li1, H. Lee1, D. Yang2 1 Chonnam National University Medical School, Gwagnju, SOUTH KOREA, 2 College of Medicine, Hallym University, Seoul, SOUTH KOREA uropark@gmail.com Objective: Oxytocin (OT) is involved in human reproduction and serves an important role in sexual arousal. Previous studies have documented that OT levels increase during sexual stimulation and arousal with a peak during orgasm in women. The purpose of this study was to investigate the effect of OT on vaginal tissue contractility in normal and castrated rats. Design and Method: Female Sprague-Dawley rats (230–240 g, n=30) were divided into three groups: control (n=10), bilateral ovariectomy (Ovx, n=10), and bilateral ovariectomy followed by subcutaneous injections of 17β-estradiol (Ovx+Est, 50 μg/kg/day, n=10). After 4 weeks, OT receptor level and distribution was assessed in rat vaginal tissue by Western blot analyses and immunohistochemistry. In organ baths, OT-induced changes in isometric tension were also assessed in isolated strips of vaginal tissue. Results: The OT receptor was well localized in subepithelial connective tissue and vaginal smooth muscle. Exogenous application of OT (10-9 10-5 M.) showed a dose dependent contractile effect. In the Ovx groups, the contractile effects of OT were significantly decreased compared to control and Ovx+Est groups (p<0.05). Conclusions: These data suggest that OT receptor may have a role in female sexual function. Further studies are needed to evaluate the role of oxytocin in female sexual arousal response. ABSTRACTS, Klinička psihologija 9 (2016), 1, 5-190S, Klinička psihologija 9 (2016), 1, 5-190 130 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0004 DISGUST SENSITIVITY, SEXUAL BELIEFS AND ORIENTATION TO SOCIAL DOMINATION IN FEMALE BDSM AND NON-BDSM PRACTITIONERS K. Jaksic, M. Nekic University of Zadar, Department of Psychology, Zadar, CROATIA marinanekic@hotmail.com Objective: Individual differences between BDSM practitioners and non-practitioners are mostly operationalized through the Big Five or clinical personality models. We take different approach and explore other, theoretically relevant, constructs: disgust sensitivity, sexual beliefs, and orientation to social domination. Assumptions for the research we find in the work of McCarey (1973, Moser, 1999), who suggests that BDSM engagement is associated with sexual disgust sensitivity, and in the work of Jozifkova et al. (2012), who theorize that rank disparity between partners is related to sexual excitement. Design and Method: On-line survey was made with 209 female participants (33 BDSM practitioners). Measures were The Three Domains of Disgust Scale, Social Dominance Orientation Scale, Men Should Dominate Scale, and Women Should Dominate Scale. Results: BDSM practitioners report lower sexual disgust sensitivity. Marginal trend (p=.06) is seen for the support of group-based dominance (BDSM practitioners score higher). Groups don`t differ in their beliefs regarding both men and women sexual dominance, but intragroup difference exists for BDSM group on the beliefs of men sexual dominance. Correlations analysis suggest possibly stronger positive relation between beliefs on women sexual dominance and group based dominance for the BDSM group. Sexual disgust sensitivity in this group is positively correlated with both beliefs on men and women sexual dominance. Conclusions: Results do not support McCarey ́s disgust hypothesis. Interpersonal and group rank disparity needs to be researched together with the sexual disgust sensitivity in the BDSM group. ABSTRACTS, Klinička psihologija 9 (2016), 1, 5-190S, Klinička psihologija 9 (2016), 1, 5-190 131 © “Naklada Slap”, 2016. Sva prava pridržana. DOI: 10.21465/2016-KP-P-0005 EXTRADYADIC INVOLVEMENT IN DATING RELATIONSHIPS: PREVALENCE AND FACTOR STRUCTURE OF THE EXTRADYADIC BEHAVIOR INVENTORY A. Martins1, R. Andrade1, I. Narciso2, M.C. Canavarro1, F.M. Dattilio3, M. Pereira1 1 Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra,2 Faculty of Psychology, University of Lisbon, Lisbon, PORTUGAL, 3 Harvard Medical School, Boston, Ma, USA alexandrafrsmart