Functionality assessment of microcrystalline cellulose derived from rice husk as a pharmaceutical excipient

Herein, microcrystalline cellulose obtained from rice husk (RH-MCC) has been evaluated for its role as a diluent in ascorbic acid tablet formulation, as well as disintegrant in dicalcium phosphate (DCP) compacts. Critical material attributes of the MCC including morphology (SEM), thermal behavior (DSC), micromeritic, flow, swelling and sorption properties correlated well to its roles, and are comparable to the well-known commercial brand, Avicel PH 101. Consequently, RH-MCC could function as a potential pharmaceutical excipient.