Effects of Subthalamic Deep Brain Stimulation on Neuropsychiatric Fluctuations in Patients with Parkinson's Disease (psychostim Study)

Neuropsychiatric Fluctuations (NPF) are frequent and disabling non-motor symptoms of advanced Parkinson's Disease (PD). Little is known about the effects of bilateral subthalamic deep brain stimulation (STN-DBS) on NPF. We aimed at evaluating the effects of STN DBS on acute NPF using a dedicated scale, the Neuropsychiatric Fluctuation Scale (NFS). NFS combines items derived from various neuropsychiatric scales, in a simple, motor phase-dependant score (from −30 to +30 points).