Clear cell odontogenic carcinoma in posterior region of mandible: a case report

Clear cell odontogenic carcinoma (CCOC) is a rare intraosseous carcinoma, potentially aggressive, capable of frequent recurrences loco-regional and metastasis. Here, we describe a 28-year-old female patient presenting a swelling in the region of the teeth 43 to 45. Radiographically, was observed hypodense associated with hyperdense areas causing buccal and lingual expansion. In the microscopic analysis, it was reported odontogenic neoplasia characterized by islands and cords of epithelial cells with peripheral composed by cuboidal/cubic cells, arranged in palisade, with inverted polarity, sometimes vacuolized, and centrally composed of polygonal and basaloid cells, some of them, with clear cytoplasm. The neoplasia presented no capsule and produced peripheral bone resorption and perivascular invasion. The periodic acid–Schiff reaction showed glycogen positive and immunohistochemical analysis revealed intense positivity for CK14, consistent with clear cell odontogenic carcinoma. The patient was submitted to resection surgery, where the same histologic pattern was observed, and is under clinical-radiographic follow-up. Clear cell odontogenic carcinoma (CCOC) is a rare intraosseous carcinoma, potentially aggressive, capable of frequent recurrences loco-regional and metastasis. Here, we describe a 28-year-old female patient presenting a swelling in the region of the teeth 43 to 45. Radiographically, was observed hypodense associated with hyperdense areas causing buccal and lingual expansion. In the microscopic analysis, it was reported odontogenic neoplasia characterized by islands and cords of epithelial cells with peripheral composed by cuboidal/cubic cells, arranged in palisade, with inverted polarity, sometimes vacuolized, and centrally composed of polygonal and basaloid cells, some of them, with clear cytoplasm. The neoplasia presented no capsule and produced peripheral bone resorption and perivascular invasion. The periodic acid–Schiff reaction showed glycogen positive and immunohistochemical analysis revealed intense positivity for CK14, consistent with clear cell odontogenic carcinoma. The patient was submitted to resection surgery, where the same histologic pattern was observed, and is under clinical-radiographic follow-up.