The Preparation of Au NPs/RGO-MoO 2 Composite Modified Electrode and Simultaneous Detection of Acetaminophen and Dopamine

Abstract Dopamine (DA) exists in human body fluids and is the most basic metabolite of the human body, and it is an important neurotransmitter in the central nervous system of animals. Acetaminophen (AMP) is commonly used as cold medicine to treat fever and relieve pain. The safe dosage is very important to human health. Therefore, it is very important to construct an accurate, efficient and fast detection method for detecting AMP and DA. In this paper, Au NPs/RGO-MoO 2 composite modified electrode was prepared for the detection of AMP and DA , We can see that the synergy between RGO-MoO 2 nanomaterials and Au NPs and can promote the electrochemical reaction of AMP and DA, and the oxidation peak potential difference is greater than 180 mV. The linear range of the sensor for detecting AMP is 0.05~320 μmol/L while the linear range of DA is 0.6~260 μmol/L, and the detection limits are 7.2 nmol/L and 13 nmol/L (S/N=3) respectively. The Au NPs/ RGO-MoO 2 /GCE sensor can be used for the detection of AMP and DA in actual samples because of its excellent characteristics such as wide linear range, lower detection limit, excellent reproducibility, stability, and high selectivity