Recent Advances on the Synthesis of Β-Lactams by Involving Carbon Monoxide

beta- Lactam compounds are antibiotics with high biological activity and high application value. Design and synthesis of beta-lactams with high efficiency and high selectivity have always been a hot issue in organic chemistry. Because of the carbonyl group in the ring structure, the carbonylation reaction between substrate and carbon monoxide (CO) has also developed into a new method for synthesis of beta-lactams, which can be used to synthesize novel and diverse structures in one step. In this paper, the carbonylation of different substrates with CO to synthesize beta-lactams in recent years is reviewed, and the existing problems and future development of this strategy are prospected.