Immune Infiltration Characteristics of Related Receptor Signaling Pathways in Primary Sjögren’s Syndrome

Background: Primary Sjögren’s Syndrome (pSS) is a chronic systemic autoimmune disease characterized by a broad spectrum of clinical features. It is considered to be associated with immune cells and genetic. Since the pathogenesis of pSS has not been studied thoroughly enough, it is significant to explore the relevant mechanisms using bioinformatics methods.Methods: We downloaded the GSE84844, GSE66795 and GSE51092 datasets from the GEO database, and then conducted a comprehensive bioinformatics analysis including differentially expressed genes (DEGs), functional enrichment pathways and immune infiltration characteristics. Results：DEGs analysis identified a total of 89 up-regulated genes and 11 down-regulated genes in the dataset. These DEGs were enriched in NOD-like and RIG-I-like receptor signaling pathway, which were significantly associated with the expression of immune cells such as neutrophils and activated dendritic cells, respectively.Conclusion: The NOD-like and RIG-I-like receptor signaling pathway and the pathogenesis of pSS may be closely associated. Neutrophils and dendritic cells also play an important role in pSS, and the expression of these two kinds of cells is closely associated with the signaling pathways of NOD-like and RIG-I-like receptors.