VAC_19-System biology analysis of THP1 cell line as in vitro model to evaluate yellow fever vaccine

Introduction: Bio-Manguinhos is the world’s biggest producer of the attenuated yellow fever vaccine (YFV17DD), a centennial product recognized as one of the most successful vaccines ever developed in terms of efficacy and safety. Besides, it is considered the standard vaccine to investigate the dynamics and quality of an ideal vaccine. Although, YFV17DD present rare cases of adverse events post-vaccination, Bio-Manguinhos has been seeking new vaccine design strategies that achieve the necessary safety in AEPV risk groups. The production of new immunobiologicals is no longer empirical and has been improved by technical-scientific approaches, demanding deeper interdisciplinary studies in different fields such as genetics and immunology. In this context, systems biology has been increasingly relevant and could help to design new vaccines.