Novel and highly potent ATR inhibitor M 4344 kills cancer cells with replication stress , and 1 enhances the chemotherapeutic activity of widely used DNA damaging agents 2 3

Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and 1 enhances the chemotherapeutic activity of widely used DNA damaging agents 2 3 Ukhyun Jo , Ilya S. Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, 4 Se Hyun Kim , Vinodh N. Rajapakse, Fathi Elloumi , Nobuyuki Takahashi, Christopher W. 5 Schultz, Anish Thomas, Frank T. Zenke and Yves Pommier * 6 7 1 Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for 8 Cancer Research, National Cancer Institute, Bethesda, MD, USA. 9 2 Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National 10 Cancer Institute, Bethesda, MD, USA. 11 3 Merck KGaA, Biopharma R&D, Translational Innovation Platform Oncology, Darmstadt, 12 Germany. 13 4 Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul 14 National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. 15 General Dynamics Information Technology Inc., 3211 Jermantown Road, Fairfax, VA 22030, 16 USA 17 6 Lead Contact 18 * Correspondence: Yves Pommier (pommier@nih.gov), Ukhyun Jo (ukhyun.jo@nih.gov) 19