Genetic Interaction Between the Non-homologous End Joining Factors during B and T Lymphocyte Development: In Vivo Mouse Models

DNA double-strand breaks (DSBs) are generated both extrinsically, for example, by chemotherapeutic agents, and physiologically, for example, during V(D)J recombination in developing B and T lymphocytes, and class switch recombination (CSR) in activated mature B cells.1,2 The DNA damage response (DDR) pathway is initiated upon the induction of DSBs. Ataxia telangiectasia mutated (ATM) is a DDR regulator protein kinase that phosphorylates Received: 25 April 2020 | Revised: 7 June 2020 | Accepted: 6 July 2020 DOI: 10.1111/sji.12936