Machine Learning Provides Evidence that Stroke Risk is Not Linear : 1 The Non-Linear Framingham Stroke Risk Score 2 3 The Non-linear Framingham Stroke Risk Score

1. Operations Research Center, Massachusetts Institute of Technology, Cambridge, MA 9 2. Office of Innovation, Hartford HealthCare, Hartford, CT 10 3. Ayer Neuroscience Institute, Hartford HealthCare, Hartford, CT 11 4. Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 12 13 14 Submission Type: Research Article 15 Word count of Abstract: 279 16 Word count of Paper: 8,625 17 18 Corresponding Author: 19 Agni Orfanoudaki, 20 Operations Research Center, 21 Massachusetts Institute of Technology, 22 Cambridge, MA 02139, USA. 23 Tel: 617-586-9202 24 Email: agniorf@mit.edu 25 26 Agni Orfanoudaki agniorf@mit.edu | 27 Emma Chesley echesley@mit.edu | 28 Christian Cadisch christian.cadisch@gmail.com | 29 Barry Stein Barry.Stein@hhchealth.org | 30 Amre Nouh Amre.Nouh@hhchealth.org | 31 Mark J. Alberts Mark.Alberts@hhchealth.org | 32 Dimitris Bertsimas dbertsim@mit.edu 33 34 35 36 Deleted: J. 37