Reversal of histopathological changes in soleus muscle of denervated mice by fenoterol hydrobromide

Amelioration of denervation stress by fenoterol hydrobromide has been investigated in soleus muscle of mice. Fenoterol hydrobromide is a β2-Adrenoceptor agonist which acts an anabolic agent in skeletal muscle, because they promote hypertrophy and have potential application for enhancing muscle repair after injury. A significant increase (p<0.05) in ratio of soleus muscle to body weight was reported at every stage of study i.e. 7 to 28 days of chronic administration of fenoterol to normal innervated mice. This ratio in denervated animals showed a constant significant decline from 6.66% at day 7 to 54.54% at day 28 pointing towards stress induced by denervation in mice. Similarly, soleus muscle of denervated animals also showed a decrease in dry muscle mass. The effects of fenoterol on denervated mice healed the effects of denervation but its value was significantly below the normal innervated levels. Histopathological examination of denervated mice treated with fenoterol showed ameliorating effects in soleus muscles which showed some recovery of muscle structure towards normal profile.