Anti-inflammatory and Anti-anemic Properties of Nanocomplex Based on C60 Fullerenes and Pyrrole Core under Acute Ulcerative Colitis in Rats

Ability of C60 fullerenes to scavenge free radicals and of multy-kinase inhibitor pyrrole derivative to regulate production and activation of immune cells producing damaging free radicals, could be a rationale of hybrid nanocomplex synthesis based on them. So, therapeutic potential of nanocomplex 3-{[4-chloro-1-(4-chlorobenzyl)-2,5dioxo-2,5-dihydro-1H-pyrrole-3-yl]amino}phenyl 4-[6, 6]phenyl-C61-butanoate (C60-MI-3OH) under rat acute ulcerative colitis has been investigated.C60-MI-3OH reduced systemic inflammation under acute colitis, as evidenced by normalization of the leukocytes count in blood due to the lowering of neutrophilic granulocytes and monocytes number with simultaneous reduction of colon damage area. C60-MI-3OH abolishes development of anemia under acute colitis probably due to the decreased volume of hemorrhages as a result of intensifying the processes of colon wall healing and erythropoiesis stimulation.Complexation of pyrrole derivative having multi-kinase inhibitory activity with C60-fullerenes could potentiate the efficacy of the first one and allow the complex to be applied in low dose (0.2 mg/kg)