The novelty of our approach is to show that the order in which mutations are acquired influences tumor biology , the behavior of stem and progenitor cells , and clinical presentation

n engl j med 372;19 nejm.org may 7, 2015 1866 cells. The novelty of our approach is to show that the order in which mutations are acquired influences tumor biology, the behavior of stem and progenitor cells, and clinical presentation. David G. Kent, Ph.D. Christina A. Ortmann, M.D. Anthony R. Green, F.R.C.Path., F.Med.Sci. University of Cambridge Cambridge, United Kingdom arg1000@cam.ac.uk Since publication of their article, the authors report no further potential conflict of interest.