Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis

Michael Wallisch,Yasser Khder,Monica T. Hinds,Erik I. Tucker,Dan Bloomfield, Andras Gruber

Blood（2021）

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摘要

Background: Factor XI (FXI) inhibition demonstrated strong efficacy in preventing thrombus formation in preclinical and clinical models of arterial and venous thrombosis. However, the effect of FXI inhibition in halting the progression of a formed clot remains largely unknown.

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