Unraveling molecular mechanism underlying biomaterial and stem cells interaction during cell fate commitment using high throughput data analysis

•Effect of different biomaterials on stem cell growth and differentiation.•Understand the effect of cell of origin on the differentiation potential of multipotent stem cells.•Dimensionality (2D versus 3D) and the degradability of biomaterials affects the way that the cells are able to grow and differentiate at the transcriptional level.•Cell of origin is an important factor in determining the response of stem cells to same biomaterial.