Identification of a Therapeutic Interfering Particle—a Single-Dose SARS-CoV-2 Antiviral Intervention with a High Barrier to Resistance

Sonali Chaturvedi,Gustavo Vasen,Michael Pablo,Xinyue Chen,Nathan Beutler,Arjun Kumar,Elizabeth Tanner,Sylvia Illouz, Donna Rahgoshay,John Burnett,Leo Holguin,Pei-Yi Chen,Blaise Ndjamen,Melanie Ott,Robert Rodick,Thomas Rogers,Davey M. Smith,Leor S. Weinberger

Cell（2021）

Cited 36|Views30

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Key words

SARS-CoV-2,coronavirus,variants,evolution,defective interfering particles,lipid nanoparticle,therapeutic interfering particles,RNA,intranasal,virus-like particle

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