Acquired Von Willebrand Syndrome Secondary to Lymphoproliferative Disorders: A Case Series from Two French Centers.

Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with approximately 700 cases reported worldwide and an estimated prevalence of 0.04%. This syndrome results from an acquired quantitative and/or qualitative deficiency in Von Willebrand Factor (VWF) and mostly occurs secondary to an underlying disorder. It was first described in 1968 in a patient with systemic lupus erythematosus [1]. This syndrome is essentially characterized by cutaneous and mucosal bleeding similarly to inherited von Willebrand disease.