Significance of Soluble CD40 Ligand (sCD40L) and Matrix Metalloproteinase-9 in Risk Stratification of Acute Coronary Syndrome

The objective was to analyze the differential expression of serum soluble CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) in different stratifications of acute coronary syndrome, and to provide molecular markers for the stratification of acute coronary syndrome. A total of 200 patients with acute coronary syndrome who were treated in our hospital from October 2016 to October 2017 were selected and divided into low-risk group, intermediate-risk group and high-risk group according to GRACE score. 50 healthy volunteers over the same period were selected as control group. The serum of patients was collected, and the levels of sCD40L, MMP-9 and CRP in serum were determined by enzyme-linked immunosorbent assay (ELISA). The relationship between sCD40L, MMP-9, and different stratifications of patients with acute coronary syndrome was analyzed. Compared with healthy population, sCD40L, MMP-9 and hs-CRP in ACS patients were significantly higher (p < 0.001). Serum sCD40L, MMP-9, and hs-CRP levels were inconsistent in patients with different stratifications, and the difference was statistically significant (p < 0.05), and the expressions of sCD40L, MMP-9, and hs-CRP in serum were elevated with increased stratification. The severity was positively correlated with sCD40L and MMP-9 (r = 0.561, r = 0.574, p < 0.01). sCD40L and MMP-9 can be used as molecular markers for disease stratification in patients with acute coronary syndrome.