461P Molecular Tumor Profiling and Matched Molecular Targeted Treatment in Metastatic Young-Onset Colorectal Cancer (YOCR)

I. Baraibar Argota,J. Ros,R. Comas,S. Aguilar,F. Salva,A. Garcia,J. L. Cuadra Urteaga,N. Saoudi Gonzalez,N. Mulet Margalef,J. Hernando,J. Capdevila,M. Marti,E. Espin,E. Garralda, P. Nuciforo,R. Dienstmann,A. Vivancos,J. Tabernero,M. E. Elez Fernandez

Annals of oncology（2021）

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摘要

Young-onset colorectal cancer (YOCR) is defined as diagnosis below the age of 50. The incidence of YOCRC is increasing at an alarming rate, but causes and pathogenesis remain unknown and YOCRC is not well characterized. We aimed to characterize the molecular characteristics of YOCRC in patients (pts) diagnosed at our centre and to evaluate the impact of molecular tumor profiling (MTP) in ameliorating the current development in metastatic YOCR.

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