Single‐cell TCR Repertoire Analysis Reveals Highly Polyclonal Composition of Human Intraepithelial CD8+ Αβ T Lymphocytes in Untreated Celiac Disease

We compared the alpha beta T-cell receptor repertoires of CD8(+) alpha beta intraepithelial lymphocytes from celiac disease patients and healthy subjects by single-cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.