Granzyme B Expression In Conventional Cd4+T-Cells Is Strongly Associated With Increased Relapse Rate During First 6 Months After Allo-Hsct

Introduction. Granzyme B (GZMB) is a serine protease commonly found in the granules of cytotoxic lymphocytes and natural killer cells. It is secreted with the pore forming protein perforin and mediates apoptosis in target cells. Previously we have already reported about impact of GZMB expression in T-regulatory cells on acute graft-versus-host disease (aGVHD) development (Drokov et al. 2017). Recent publication of W. Du et al. shown that GZMB in conventional CD4+CD25- T-cells (Tcon) contributes to the optimal graft-versus-tumor (GVT) effect in mouse models. Here we reported data about GZMB expression in Tcon on day +30 and its influence on relapse rate during first 6 months in allo-HSCT patients.