Multi-Omics of Aurora Inhibition Induced Polyploidy Reveals Mechanisms of Disease Relapse in MYC/BCL2-Addicted High Grade B-Cell Lymphoma

Shariful Islam,Andrew Paek,Michael Hammer,Savithri Rangarajan,Robert Ruijtenbeek,Laurence Cooke,Eric Weterings,Daruka Mahadevan

Blood（2018）

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摘要

Key Points•MYC mediated upregulation of TPX2, KPNA2 and RanGAP1 dysregulate the spindle assembly checkpoint in drug-induced polyploid cells.•Drug-induced polyploid cells re-enter cell cycle via multipolar mitosis, fission or budding, a mechanism of disease relapse.

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