Synthesis And Biological Activity Of Pyridopyridazin-6-One P38 Alpha Map Kinase Inhibitors. Part 2

Robert M. Tynebor,Meng-Hsin Chen,Swaminathan R. Natarajan,Edward A. O'Neill,James E. Thompson,Catherine E. Fitzgerald,Stephen J. O'Keefe,James B. Doherty

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2012）

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摘要

This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38 alpha activity and 24 h coverage in the rat arthritis efficacy model. (c) 2012 Elsevier Ltd. All rights reserved.

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关键词

p38 alpha MAP kinase inhibitors, Pyridopyridazin-6-one, Heterocycles, Inflammation, Rheumatoid arthritis

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