Correlation of Hcy, inflammation level and cerebral infarction in hypertensive patients

Objective: Our study aimed to investigate the correlation between serum inflammatory factors and Hcy levels with the occurrence of acute cerebral infarction in hypertensive patients. Methods: A total of 82 patients with acute cerebral infarction and hypertension in Xuzhou Central Hospital were enrolled as the study group, while 54 patients with acute single cerebral infarction were selected as the infarct group, and 30 healthy individuals were included as the normal group. The contents of serum Hcy level and inflammatory factors (IL-6, IL-8, TNF-alpha) at the 1st day after admission were detected. Pearson's correlation analysis was employed to assess the relations of the IL-6, IL-8, TNF-alpha and Hcy levels in patients with acute cerebral infarction and hypertension. Results: The levels of IL-6, IL-8, TNF-alpha and Hcy in the study group were significantly higher than those in the infarct and normal groups, while the IL-6, IL-8, TNF-alpha and Hcy levels in the infarct group were also significantly higher than those in the normal group (P<0.05). Among-the 80 patients in the study group, 76 patients were identified with high levels of Hcy, with an average value of 17.4 +/- 6.1 mu mol/L, among which, 63 cases were diagnosed with H-type hypertension, with an average Hcy content of 20.1 +/- 5.4 mu mol/L. While 6 patients with hypertension were measured with an average Hcy content of 9.1 +/- 5.4 mu mol/L. In the study group, the contents of IL-6, IL-8 and TNF-alpha were significantly correlated with Hcy level, while those levels in patients with different volumes of infarction were higher than those in the normal group (P<0.05). Conclusion: Our data indicate that IL-6, IL-8 and TNF-alpha play an important role in the formation of arterial plaque and have impact on the infarct volume.