Effect Of Tslp On The Function Of Platelets And Il-25 In Chronic Obstructive Pulmonary Disease

Objective: To investigate the effect of thymic stromal lymphopoietin (TSLP) on the function of platelets and IL-25 in patients with chronic obstructive pulmonary disease (COPD) and its monitoring value. Methods: 126 patients with COPD and 119 healthy subjects were selected for retrospective analysis. TSLP and IL-25 levels in the serum were measured using enzyme-linked immunosorbent assay (ELISA). The platelet level was detected using the automatic blood cell analyzer, while platelet aggregation ability was detected using the platelet aggregation analyzer. The correlation between TSLP and the partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) was analyzed. Results: The TSLP in the COPD group was significantly higher than that in the control group (P<0.001). IL-25, platelet count, and platelet aggregation rate in the high TSLP group were significantly higher than those in the low TSLP group (P<0.001). The PaO2 in the high TSLP group was significantly lower than that in the low-TSLP group (P<0.001), while the PaCO2 in the high-TSLP group was significantly higher than that in the low-TSLP group (P<0.001). Linear correlation analysis showed that TSLP was negatively correlated with PaO2(r=-0.880, P<0.001) but positively correlated with PaCO2 (r=0.878, P<0.001). Conclusion: The expression of TSLP can be used as an effective indicator for monitoring the severity of COPD in patients, and is considered as a potential target for the treatment of COPD.