Association of Rs11614913 (C > T) in Mir-196A2 with Breast Cancer and Gastric Cancer: a Meta-Analysis

Previous studies have suggested that single nucleotide polymorphism (SNP) rs11614913 (C > T) in miR-196a2 is associated with a reduced risk of breast cancer (BC) and gastric cancer (GC), but the evidence has been conflicting. To obtain a better assessment of the association between rs11614913 in miR-196a2 and cancer risk, the present meta-analysis was conducted using systematic reviews of PubMed, Embase, Wanfang, and China's National Knowledge Infrastructure. Moreover, 95% confidence intervals and pooled odds ratios were used to assess the association with breast cancer and gastric cancer. A total of 6 case-control studies of BC and 6 case-control studies of GC were included. The present meta-analysis revealed that rs11614913 in miR-196a2 was significant related with decreased risk of GC (TT vs CC: OR = 0.644, 95% CI = 0.475-0.874, P = 0.005). However, rs11614913 in miR-196a2 was not related to a reduced risk of breast cancer in any of the models. Meta-analysis results demonstrate that rs11614913 in miR-196a2 is related to a significantly decreased risk of gastric cancer. However, there was no significant association between miR-196a2 rs11614913 and susceptibility to BC.