Formulation Preparation And Physical Characteristics Of Cr Diltiazem Hcl With Different Polymer Combinations

The drug delivery system (DDS) changes the formulation techniques and have made a great break-through progress. Started a simplest pill formulation and gradually improve the techniques regarding the new symptoms and indications and breakthrough in the developments of formulation to more sophisticated controlled release formulations. Polymers are the major components for the development of controlled release formulations. Chemicals included the magnesium stearate, Diltiazem HCI, lactose, polymers (cabapol and Eudragit derivative) monobasic potassium phosphate, starch, CMC, and other of analytical grade. Friabilator, Disintegration Apparatus, Syringes, Beakers, Dissolution Apparatus, Balance. UV-Visible Spectrophotometer, PH-meter, Hardness tester, volumetric flasks, Test tubes, Single Punch Machine, Verniar caliper and pre-formulation studies done. This study concluded that he different types of polymers were used in different combination which showed its physical characteristics according to the specifications mentioned in standards.