Design and Discovery of N -(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl )-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic Savithri Ramurthy , Benjamin R. Taft , Robert J. Aversa , Paul A. Barsanti , Matthew T. Burger , Yan Lou , Gisele A. Nishiguchi , Alice Rico , Lina Setti , Aaron Smith , Sharadha Subramanian , Victoriano Tamez , Huw Tanner , Lifeng Wan , Cheng Hu , Brent A. Appleton , Mulugeta Mamo , Laura Tandeske , John E. Tellew , Shenlin Huang , Qn Yue , Apurva Cliaudliary , Hung Tian , Raman Iyer , A. Quamrul Hassan , Lesley A. Mathews Griner , Laura R. La Bonte , Vesselina G. Cooke , Anne Van Abbema , Hanne Merritt , Kalyani Gampa , Fei Feng , Jing Yuan , Yuji Mishina , Yingyun Wang , Jacob R. Haling , Sepideh Vaziri , Mohammad Hekmat-Nejad , Valery Polyakov , Richard Zang , Vijay Sethuraman , Payman Amiri , Mallika Singh , William R. Sellers , Emma Lees , Wenlin Shao , Michael P. Dillon , Darrin D. Stuart JOURNAL OF MEDICINAL CHEMISTRY（2020）
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