Inhibition Of Beta-Hematin Formation Of Colombian Species Of Piper App. And Calophyllum Spp. As Potential Antimalarial Agents

New antimalarial agents from plants are studied as alternatives in the treatment of malaria. "The main antimalarials such as chloroquine have several mechanisms of action against parasites. one of which is the inhibition of polymerization of the heme group, a model that has allowed the design of new antimalarial candidates. In this sense the objective of this work was to evaluate extracts of genus Piper and Calophyllum plants on the inhibition capacity of ii-hematin. Inhibitory concentrations of beta-hematin are reported from 40 extracts of different polarity obtained from the species P. piedecuestanum, C. brasiliense. C. longin-forium, and Calophyllum. sp. 19 extracts showed a greater potential to inhibit beta-hematin with IC50 < 3 mg/ml. These activities mainly support future studies with the genus Calophyllum in the development and discovery of new antiplasmodial substances with known modes of action.